Two new studies published in the April 2011 issue of The Journal of Nutrition suggest that whey protein enhances muscle synthesis after resistance training and that the dairy protein may help us store less body fat. 
In the first study, researchers set out to find out if whey protein enhanced muscle protein synthesis a full 24 hours after resistance training.
The study included 15 college-aged men who performed either 1) 90% 1 Rep-Max (RM) efforts to failure, 2) 30% 1 RM effort to make the workload of the 90% 1 RM or 3) 30% 1 RM to failure. The researchers then had the subjects return to the lab 24 hours later and they were provided 15 grams whey protein, then the researchers monitored markers for muscle mass synthesis. All results were compared to a control feeding of 15 grams whey protein when the subjects were well rested.
The results showed that muscle synthesis was increased after consuming whey protein in both the 90% and 30% 1 RM to failure but not in the non-failure group. In fact, the 30% of 1 RM group had the biggest boost in markers for muscle synthesis, indicating that you don’t have to lift mega weights to get results, but you do need to lift to failure.
Whey protein is rapidly digested and produces a large ‘spike’ in essential amino acids in the blood. It also boosts blood leucine—a branch chain amino acid important for anabolic signaling—more than other types of protein.
Nicholas Burd, Ph.D., Department of Kinesiology, McMaster University
Whey protein is rapidly digested and produces a large ‘spike’ in essential amino acids in the blood. It also boosts blood leucine—a branch chain amino acid important for anabolic signaling—more than other types of protein.
Nicholas Burd, Ph.D., Department of Kinesiology, McMaster University
In the second study, researchers set out to determine if whey protein provides protection against high-fat, high-calorie diets.
In this animal study, mice were put on a high-fat, weight-gaining diet for 11 weeks. Half of the mice were given whey protein isolate in their water and the other half served as the control. Even though the diets of the mice were matched for calories, the animals given whey protein isolate had higher basal metabolic rate, increased fat burning and were less likely to gain body fat while on the high-fat diet, compared to mice not receiving whey protein isolate. The whey protein animals had a 42% lower rate of weight gain and 32% less body fat gains and 7.5% more lean body fat compared to animals on the control diet. While whey protein cannot prevent weight gain when calories exceed daily requirements, it may make the body less efficient at storing excess calories as fat.
Whey Better Than The Rest
There are hundreds of studies with humans and animals that have shown muscle enhancing benefits of whey protein. But whey protein alone will not make you stronger or leaner, but it may enhance your strength training and calorie-controlled diet. In addition, eating skim and low-fat dairy foods may provide the same benefits as whey protein supplements.
When it comes to whey specifically, sports dietitian Tavis Piattoly MS, RD, who works at Elmwood Fitness and is the sports nutritionists for the New Orleans Saints (Who Dat?), recommends taking 15-20 grams whey protein before and especially after strength workouts. He adds that whey protein hydrolysate may have the greatest impact on protein synthesis but whey isolate or concentrate are also good. Many products have a blend of these isolated whey compounds.
When looking for a whey supplement, check the ingredient list to make sure whey protein hydrolysate, isolate or concentrate (or a combination) is one of the first ingredients. I have tried GNC’s AMP Amplified Wheybolic Extreme 60, but use one scoop (not the recommended three scoops) for 20 grams whey protein. Many “recovery” beverages are made with protein blends (soy, casein, albumin and whey) and provide much more carbohydrate than protein and are surprisingly high in calories. They’re good options for endurance athletes but may not be the best for those trying to manage calories to optimize leanness.
As a follow up to this post, I’ll be providing the top whey supplement picks from sports nutritionists working with the nation’s best professional athletes. Stay tuned.
How Much Protein is Enough?
| Sedentary | 0.8-1.0g per kg (0.36-0.45g per lb) |
| Recreational exercisers | 0.8-1.0g per kg (0.36-0.45g per lb) |
| Serious resistance athletes:
early in training |
1.5-1.7g per kg (0.68-0.77g per lb) |
| Serious resistance athletes:
established training program |
1.0-1.2g per kg (0.45-0.55g per lb)
|
| Serious Endurance Athlete | 1.4-1.6g per kg (0.64-0.73g per lb)
|
| Teenage Athletes | 1.5-2.0g per kg (0.68-0.91g per lb)
|
Source: Bell-Wilson and Upton, Energy to Burn: The Ultimate Nutrition Guide to Fuel Your Active Life, Wiley 2009




This was a really good article. I have started doing my whey protein shakes daily, to make sure that I’m getting in my protein for the day and helping with control of weight gain. Keep up the great work, I sure do enjoy visting website and reading your articles.
This is a great article. Does it say exactly the best way to get whey. I know they have shakes, bars, etc. ?
Wondering- does anyone have a list of leucine amounts in common foods, i.e. glass of milk, cup of yogurt, 4 oz chicken breast, etc….
Traci,
Great comment. I was going to search to see if one exists. I’m sure it would not be comprehensive but maybe there is a way to search usda database by leucine….
I’m checking into it
J
What everyone seems to overlook is that the muscles have a maximum size they will attain. Taking whey might help you build more muscle sooner (and how much sooner would depend on a lot of factors–a week? two weeks?) so what’s the big deal?
I find the research fascinating, but am concerned with the take away. I wonder what would have happened with other types of protein? Since whey is the only one measured, it is easy to jump on the bandwagon.
The “high” fat diet wasn’t specified. How high? What else was in that chow? It would be interesting to see how the added protein impacts fat metabolism.
There is no mention of the carbohydrate content nor it’s source. (I’m guessing there is carbohydrate) One possible hypothesis for this action is that protein is buffering the glycemic impact of the carbohydrate component of the chow. Is it possible that protein has a role impacting how enegy is partitioned–either stored or used for energy?
For almost 20 years I have observed this phenomena in my practice. Most of my clients who increase protein content have the same experience. They gain muscle mass and lose fat weight. The muscle mass gain stops when their reach their genetic potential, but they can continue to mobilize fat more effectively eating enough protein.
The amount of protein needed to do this is more than the RDA recommendations, and sometimes more than the recommendations listed above. The fat content in the diet makes little difference except if someone is overeating.
The other concern is amount and type of carbohydrate. The range is wide. Some clients enjoy close to 50% of their calories from a wide range of complex carbohydrates, others don’t tolerate much more than vegetables and do best when they eat 30-35% of their calories from carbohydrate, sometimes less. Only the most insulin sensitive folks lose fat weight eating a significant amount of carbohydrate from refined sources.
I find the range of insulin sensitivity and secretion is wide across the population, even for athletes. I think this is a key issue when it comes to energy metabolism.
Great information–thanks for summarizing for us.
@ Bonnie, you mention insulin sensitivity. Out of curiosity, how do you determine a person’s level of insulin sensitivity? I ask because one of the providers that I work with inquired about serum levels of insulin and using this to determine “insulin resistance” vs insulin clamp, etc.
As for leucine content, it’s not available on the FNIC website, but I did find some sources here (not sure how reliable they are):
http://wholefoodcatalog.info/nutrient/leucine/milks/
But your body still needs food while you are sleeping..Research shows that consuming casein protein right before bedtime which your body absorbs slowly can prevent or diminish the breakdown of muscle fibers. If you want to make sure that your muscles are well fed while you sleep you may want to try casein protein found in milk with which you can prepare a shake right before bedtime.
The fast black